SUMMARYA study published Monday in The Lancet Regional Health - Americas found that the share of U.S. cancer deaths attributable to alcohol rose more than 58% among adults 20 and older over the past 33 years. Alcohol-linked cancer deaths increased from 11,361 in 1990 to 23,126 in 2023, with the largest effects seen in men and adults 55 and older. Researchers tied alcohol to higher risks for liver, esophageal, colorectal, and breast cancers.
CNN reports that alcohol "may play a greater role in death from numerous types of cancers in the United States than previously known, according to a new study."
"While it's true that overall cancer mortality has declined, we found the percentage of cancer deaths proportionally attributable to alcohol rose over 58% in people 20 and older over the last 33 years," said the study's first author Dr. Chinmay Jani... It didn't take much alcohol to raise one's risk - about one standard drink a day, every day, Jani said. In the US, a standard drink is 12 ounces of regular beer, 5 ounces of wine or 1.5 ounces of 80-proof liquor...
Alcohol is ethanol or ethyl alcohol, which is broken down by the liver into acetaldehyde, a "probable human carcinogen," the National Cancer Institute states on its website. While the liver will further break down acetaldehyde into a harmless molecule called acetate, the process isn't foolproof: acetaldehyde may damage DNA and interfere with DNA repair before conversion into acetate is complete. Alcohol also contributes to oxidative stress, which damages DNA, proteins and cell function and creates inflammation. Drinking alcohol also weakens the cells in the mouth and throat, making them more susceptible to carcinogens. That's even more likely to occur with smoking cigarettes, a major source of acetaldehyde. In addition, alcohol interferes with the break down and absorption of key nutrients thought to decrease cancer risk - vitamins A, C, D and E as well as folates in the vitamin B complex, according to the National Cancer Institute.
The study, which was published Monday in The Lancet Regional Health - Americas journal, analyzed more than three decades of US data gathered for the Global Burden of Disease Study. The GBD study is a massive scientific effort to measure health, mortality and disabilities from hundreds of risk factors, diseases and conditions in more than 200 countries and territories. Between 1990 and 2023, the total number of yearly alcohol-linked cancer deaths more than doubled, rising from 11,361 to 23,126 in the US. Men and adults age 55 and older experienced the greatest impact; alcohol-related cancer mortality rate in older males climbed nearly 24% over the 33-year period. For men, liver cancer deaths showed the strongest link to alcohol, followed by esophageal and colorectal cancers. For women 55 and older, breast cancer was the top killer, followed by liver and colorectal cancers.